Quote:
On the ABC Nightly News this week there was an interesting segment by their new medical correspondent, Dr. Richard Besser – “The Question You Should NOT Ask Your Doctor.”
What would you think it was?
I was ready for something illegal, like don’t ask for narcotic pain meds if you aren’t hurting, but no. It was “Don’t ask for antibiotics!”
This was the perfect follow-up to something I had read recently on-line on Medscape, written by Laura A. Stokowski, RN MS in “Emerging Antibiotics: Will We Have What We Need?” about the same thing about the global problem of emerging antibiotic resistance. After reading the list of “who should be blamed,” I admit that I should probably be saying “Mea culpa” myself.
We’ve all done it if we are truthful:
That patient that we know will tell all of their friends that we did a bad job because we did not give them a prescription for antibiotics so we cave in.
That patient who just won’t budge until we do pony up a script even though we try to tell them, you don’t need it.
Those are just the reasons that fall on our shoulders. Then there are the pharmaceutical companies that don’t invest in the development of new antibiotics, the governmental agencies that don’t make it easy to do so in the first place and the agricultural industry that uses too many antibiotics in animals, thus creating resistance there as well.
How important do you think the crisis is?
Which infections kill more people in the United States every year? HIV/AIDS, TB or MRSA.
More patients die in the United States from MRSA infections than HIV/AIDS and TB combined! Startling, isn’t it.
The most life-threatening infections, coined as the “six bad bugs” are caused by a group of drug-resistant bacteria that the Infectious Diseases Society of America (IDSA) has labeled the "ESKAPE" pathogens. The pneumonic is perfect and easy to remember because they escape effects of antibiotics. (Table)
Table. The ESKAPE Pathogens
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E
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Enterococcus faecium
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Third most common cause of HCA BSI. Increasing resistance to vancomycin.
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S
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Staphylococcus aureus (MRSA)
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Emerging resistance to current drugs and significant drug toxicities. Lack of oral agents for step-down therapy
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K
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Klebsiella Escherichia coli K pneumoniae
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ESBL-producing organisms increasing in frequency and severity; associated with increasing mortality. K pneumoniae carbapenemases causing severe infections in LTCF. Few active agents; nothing in development
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A
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Acinetobacter baumannii
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Increasing worldwide, recent surge reported in hospitals.[5] Very high mortality. Carbapenem-resistant.
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P
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Pseudomonas aeruginosa
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Increasing P. aeruginosa infections in US and worldwide. Resistant to carbapenems, quinolones, aminoglycosides
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E
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Enterobacter species
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MDR HCA infections increasing; resistance via ESBLs, carbapenemases, and cephalosporinases
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HCA = healthcare associated; BSI = bloodstream infection; MRSA = methicillin resistant S aureus; ESBL = extended-spectrum beta-lactamase; LTCF = long-term care facility; MDR = multiple drug-resistant
If we as physicians, healthcare consumers, pharmaceutical companies, the agricultural industry and the world don't wake up and recognize that we have a tsunami of a problem upon us, we are going to have to wrestle with a problem that may indeed overcome us.
It sounds like the script for a science fiction film, doesn't it? The smallest organism overtaking supposedly the smartest ones? Who was the smartest organism after all.