Presented below is some promising new research. If this does prove to be helpful, it will be a bit impressive new weapon in the war against diabetic ulcers and amputations.

A Chemical Biological Strategy to Facilitate Diabetic Wound Healing
Major Gooyit, et Al.

ACS Chem. Biol., Article ASAP
DOI: 10.1021/cb4005468
Publication Date: September 20, 2013
Copyright © 2013 American Chemical Society

Abstract:
"A complication of diabetes is the inability of wounds to heal in diabetic patients. Diabetic wounds are refractory to healing due to the involvement of activated matrix metalloproteinases (MMPs), which remodel the tissue resulting in apoptosis. There are no readily available methods that identify active unregulated MMPs. With the use of a novel inhibitor-tethered resin that binds exclusively to the active forms of MMPs, coupled with proteomics, we quantified MMP-8 and MMP-9 in a mouse model of diabetic wounds. Topical treatment with a selective MMP-9 inhibitor led to acceleration of wound healing, re-epithelialization, and significantly attenuated apoptosis. In contrast, selective pharmacological inhibition of MMP-8 delayed wound healing, decreased re-epithelialization, and exhibited high apoptosis. The MMP-9 activity makes the wounds refractory to healing, whereas that of MMP-8 is beneficial. The treatment of diabetic wounds with a selective MMP-9 inhibitor holds great promise in providing heretofore-unavailable opportunities for intervention of this disease."
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