A gene therapy ointment to reverse neuropathy

In a study just published in Molecular Pain, Northwestern Medicine researchers showed that depleting GM3 through genetic modification prevented the development of neuropathy.

The researchers apply a gene therapy ointment to deplete GM3 and GM3 synthase. Thus far, this GM3-depleting ointment, applied just to the plantar surface of a diabetic’s feet will prevent or reverse the existing neuropathy. The study is available FREE:

Ganglioside GM3 synthase depletion reverses neuropathic pain and small fiber neuropathy in diet-induced diabetic mice.


  • Comments (1)
  • Interesting - but mice studies are a long way off human trials. Personally my interest is piqued after human trials are reported and repeated studies show the same finding.

    The mice here are force fed over a short time to induce diabetes. Is the effect on SFN the same as in humans with a 15+ year history of DM? Is the skin of the plantar foot comparable to the pads of a mouse? Lots of other questions to be answered ....